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Reposted by Heankel Lyons

FragileNucleosome @fnucleosome.bsky.social · 2d

🎃 🥁This Wednesday in our 1st session of spookiest month👻 at #FragileNucleosome seminar, we are excited to host @sanimr.bsky.social & Alex Federation!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Heankel Lyons

FragileNucleosome @fnucleosome.bsky.social · Sep 5

Let’s kickstart new series of #FragileNucleosome seminars! We are delighted to have @gracebower.bsky.social from Kvon lab and @creminslab.bsky.social to present their work!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Heankel Lyons

Tanja Mittag @tanjamittag.bsky.social · Jun 5

Thank you, @philipcball.bsky.social ! It was a pleasure to meet you in person!

Philip Ball @philipcball.bsky.social · Jun 5

I saw Tanja talk about this interesting work in Copenhagen a few weeks ago. Do stress condensates act as a precursor to amyloid fibrils or, on the contrary, a diversion from them? It seems the latter.
www.cell.com/molecular-ce...

Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation

The authors show that biomolecular condensates formed by prion-like domains are metastable with respect to amyloid fibrils. Interiors of metastable condensates suppress fibril formation, whereas their...

www.cell.com

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Reposted by Heankel Lyons

PacBio @pacbio.bsky.social · Jun 2

Lou Gehrig’s courage brought ALS to national attention. On Lou Gehrig Day, we honor his legacy. Join Target ALS and #PacBio in an upcoming webinar to learn how long-read sequencing is powering the largest ALS genomics study to date.

Register to learn more: bit.ly/4mFUEZo

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Heankel Lyons @heankel.bsky.social · Jun 3

Congrats! It’s on my reading list!

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Kevin Rhine @kevinrhine.bsky.social · Jun 2

Excited to share my postdoctoral research on how neuronal #aging contributes to RNA dysfunction is now online at Nature Neuroscience! Here we find that aged neurons suffer from chronic cellular stress that compromises resiliency to new stressors🧪 www.nature.com/articles/s41...

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress - Nature Neuroscience

Rhine et al. find that neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress and reduced resiliency.

www.nature.com

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Heankel Lyons @heankel.bsky.social · May 23

Happy to be back for graduation! Thankful for my mentor @bsabari.bsky.social , @utswtxid.bsky.social and family/friends who were there last night! 🙏🏼

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Faraz Mardakheh @mardakheh.bsky.social · Apr 15

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🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...

An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6

Intrinsically disordered regions (IDRs) are prevalent in RNA-binding proteins (RBPs), yet their roles in RNA interactions remain poorly defined. Here, we examined the structured and disordered RNA-bin...

www.biorxiv.org

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Eric Topol @erictopol.bsky.social · Feb 26

Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases
www.thelancet.com/journals/lan...

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Adrian Isaacs @adrianisaacs.bsky.social · Feb 25

Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf

Neuronal polyunsaturated fatty acids are protective in ALS/FTD

Nature Neuroscience - Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels...

rdcu.be

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Reposted by Heankel Lyons

Eric Topol @erictopol.bsky.social · Feb 18

Today @nature.com on how pancreatic cancer can hijack our nervous system and how denervation may be therapeutic
www.nature.com/articles/s41...

Characterization of single neurons reprogrammed by pancreatic cancer - Nature

Nature - Characterization of single neurons reprogrammed by pancreatic cancer

www.nature.com

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Jackson Hoffman @jxhoffman.bsky.social · Feb 12

Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...

RNA polymerase II coordinates histone deacetylation at active promoters

Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.

www.science.org

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Reposted by Heankel Lyons

Ina Huppertz @inahuppertz.bsky.social · Jan 14

Very proud of our first peer-reviewed paper from the lab: a review on the multifaceted role of RNA-binding proteins in the metabolic control of stem cells. Check it out! This is a truly amazing effort by my PhD student Ellie Koletsou @mpiage.bsky.social #proudPI

doi.org/10.1038/s443...

RNA-binding proteins as versatile metabolic regulators - npj Metabolic Health and Disease

npj Metabolic Health and Disease - RNA-binding proteins as versatile metabolic regulators

doi.org

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Reposted by Heankel Lyons

BrunetLab @brunetlab.bsky.social · Dec 18

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

rdcu.be

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Heankel Lyons @heankel.bsky.social · Dec 19

Wow. Fascinating work. I need to read carefully but I was wondering if infiltrated T cells have been reported in old human brain.

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FragileNucleosome @fnucleosome.bsky.social · Dec 17

👀 Less than 24 hours! Don't forget to register!

FragileNucleosome @fnucleosome.bsky.social · Dec 11

🎄🔔Ho Ho ho!😆 Our final
#FragileNucleosome
seminar of the year! We are excited to host Julia and Nithya, two amazing ECR scientists!
🗓️Don't forget to register: us06web.zoom.us/webinar/regi...

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Reposted by Heankel Lyons

Craig Kaplan @triggerloop.bsky.social · Nov 27

As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...

Controlling Transcription Elongation and Termination: More Than a Means to An End

www.sciencedirect.com

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erzbergerlab.bsky.social @erzbergerlab.bsky.social · Nov 21

Our latest paper, a fantastic collaboration with the Mendell Lab, is out. Great work by Xiaoqiang Zhu and Victor Cruz. We uncover how tRNA structural features in the ribosomal P-site modulate co-translational mRNA decay by the CCR4-NOT complex. #RNAsky #RNAbiology #translation #ribosome #cryoEM 1/5

www.science.org

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All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Nov 19

Nice to see all you chromatin & epigenetics aficionados here! As we build our network back up please repost details for our upcoming webinar this Friday!

We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇

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Reposted by Heankel Lyons

Ali Twelvetrees @dozenoaks.bsky.social · Nov 11

Trying for a molecular and cellular neurobiology starter pack - happy to add folks and connect :) #neuroskyance #cellbiology

go.bsky.app/PgEk7aF

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Ben Sabari @bsabari.bsky.social · Nov 18

I am excited to share our review published online with Nature Reviews MCB. Pilong Li, Gaofeng Pei, Heankel Lyons, and I review the current literature on the regulation of transcription by condensates, large length scale assemblies of complexes (Figure 1).

www.nature.com/articles/s41...

Transcription regulation by biomolecular condensates - Nature Reviews Molecular Cell Biology

Transcriptional condensates, which are formed through dynamic multivalent interactions between proteins, RNA and chromatin, regulate transcription by compartmentalizing its machinery in the crowded nu...

www.nature.com

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Reposted by Heankel Lyons

David Kuster @rnadavid.bsky.social · Nov 18

Biomolecular condensate starter pack!

Trying to compile & to bring together biomolecular condensate enthusiasts & critics!

Please join this non-exhaustive (sorry!) collection & just ping me for addition.

#condensates, #phaseseparation, #granules, #IDPs

go.bsky.app/NFqmffa

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Heankel Lyons @heankel.bsky.social · Nov 18

Hi @alexholehouse.bsky.social may I be added to this pack? 🙏🏼 thanks!

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Heankel Lyons @heankel.bsky.social · Nov 18

May I please be added to this list 🙏🏼 @dozenoaks.bsky.social thank you in advance :) !

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Heankel Lyons @heankel.bsky.social · Nov 18

May I please be added 🙏🏼 @dpastoors.bsky.social thanks so much in advance!

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