Riccardo Capecchi
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blepiro.bsky.social
Riccardo Capecchi
@blepiro.bsky.social
630 followers 1.6K following 120 posts
MD, PhD. Clinical Immunologist hidden inside an Internist. Sssshhhh. #medsky #immunosky #rheumatology
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blepiro.bsky.social
Riccardo Capecchi @blepiro.bsky.social · Nov 25
Our online free tool helps you perform a classification of an IgG4-RD patient according to the 2019 ACR/EuLAR classification criteria for IgG4-RD (pmid.us/31796497).
Give it a try!
davte.it/IgG4-RD.html

(Courtesy of Dr Davide Testa)

#IgG4-RD #RheumSky
The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease - PubMed
IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serological, radiological and pathological data is required for diagnosis. This work...
pmid.us
Reposted by Riccardo Capecchi
willamateurish.bsky.social
Gli Ziziani sono una setta razionalista Usa tipica dei nostri giorni: hanno gravi accuse, e sono un misto di anarchismo, culto della scienza, complottismo e adorazione dell'inferenza bayesiana. www.rollingstone.com/culture/cult... #antropologia #Nuovereligioni #NRM #NMR
The Radicalization of Ziz Lasota: How an AI Doomer Became an Accused Cult Leader
Lasota’s friends, colleagues, and family talk about how a NASA intern and Google employee wound up at the center of a bizarre string of murders
www.rollingstone.com
December 3, 2025 at 7:28 AM
Reposted by Riccardo Capecchi
yeqiaoz.bsky.social
Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @faryabi.bsky.social @vahedilab.bsky.social @atishayjay.bsky.social

tinyurl.com/4nwfbeu2
tinyurl.com/4zaw5cn7
tinyurl.com/25snbf4j
OLIVE provides rapid visualization and analysis of chromatin tracing experiments
Zhou et al. develop the optical looping interactive viewing engine (OLIVE), a web-based application for browsing and exploring user-generated and publicly available chromatin tracing datasets.
www.cell.com
December 2, 2025 at 5:30 PM
Reposted by Riccardo Capecchi
marcveld.bsky.social
The fall of a prolific science journal exposes the billion-dollar profits of scientific publishing

One of the 15 publications that put out the most studies globally has been expelled from the indexing system for irregularities.

english.elpais.com/s...
1/3
The fall of a prolific science journal exposes the billion-dollar profits of scientific publishing
One of the 15 publications that put out the most studies globally has been expelled from the indexing system for irregularities. Its publisher, Elsevier, has a 38% profit margin that reached $1.5 billion in 2024
english.elpais.com
November 30, 2025 at 7:10 PM
Reposted by Riccardo Capecchi
genesndiseases.bsky.social
This latest review synthesizes evidence on the complex relationship between metabolic dysregulation and innate #Immune memory and proposes that targeting #TrainedImmunity may offer novel strategies for diabetes intervention. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...
November 29, 2025 at 2:56 AM
Reposted by Riccardo Capecchi
feralrobots.bsky.social
Hey @nature.com, have you got an explanation for how the hell THIS happened? & especially why you accepted a paper with such a bizarre piece of genAI slop in it?!
& more to the point, why we should take you seriously at all going forward?
www.nature.com/articles/s41...
Figure 1 from a paper published in Nature (linked in post). The figure purports to be an infographic depiction of the "Overall working of the framework" for 'explainably' diagnosing autism spectrum disorder. The infographic is plainly nonsense, containing many spelling errors, nonsense words, meaningless images and graphs. Clearly created using generative AI and (crucially) NEVER CHECKED AT ANY STEP OF THE WRITING OR PUBLICATION PROCESS.
November 27, 2025 at 3:03 PM
Reposted by Riccardo Capecchi
castltrastondrs.bsky.social
#Medsky🧪#Neurosky @jama.com
#Peripheralneuropathy (PN) , defined as damage to PN , affects ~ 1% of adults worldwide. More than 200 causes of PN exist, with symptoms ranging in severity from mild toe numbness to debilitating symptoms that can require a wheelchair…
jamanetwork.com/journals/jam...
Peripheral Neuropathy: A Review
This review discusses the pathophysiology, clinical presentation, diagnosis, and treatment of length-dependent peripheral neuropathy.
jamanetwork.com
November 22, 2025 at 6:14 AM
Reposted by Riccardo Capecchi
labwaggoner.bsky.social
@natrevimmunol.nature.com Guidelines for T cell nomenclature
www.nature.com/articles/s41...
November 18, 2025 at 4:00 PM
Reposted by Riccardo Capecchi
c0nc0rdance.bsky.social
Prashant Singh in the lab of Tina Iverson at Vanderbilt published this image of the bacterial 🦠flagellar motor, a detailed molecular model made possibly by CryoEM 🔬.

The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
November 17, 2025 at 10:31 PM
blepiro.bsky.social
It's starting the AIpocalypse
kateross.bsky.social Kate Ross @kateross.bsky.social · 16d
Billionaire Peter Thiel’s latest 13F didn’t show off a mere trim, but a full-blown exit from AI bellwether Nvidia (NVDA).
November 17, 2025 at 5:21 AM
Reposted by Riccardo Capecchi
olivia.science
just sharing here as I was reminded it's on github, in case people wanna make copies: github.com/oliviaguest/...

the cogsci hexagon: A visual depiction of the connections between the Cognitive Sciences
the cogsci hexagon, clockwise from 12 o'clock: philosophy, linguistics, anthropology, neuroscience, artificial intelligence, psychology
November 16, 2025 at 2:16 PM
Reposted by Riccardo Capecchi
oddletters.bsky.social
sts researchers: :spend decades tracing the way well-intentioned design choices constrained by culture, capital, and the material environment can have negative outcomes in aggregate:

ai companies: lets put a chatbot in a doll that tells kids to set fires

futurism.com/artificial-i...
AI-Powered Toys Caught Telling 5-Year-Olds How to Find Knives and Start Fires With Matches
AI-powered toys are flying off the shelves -- but they're engaging in horrifically inappropriate conversations with children.
futurism.com
November 13, 2025 at 2:34 PM
Reposted by Riccardo Capecchi
olivia.science
All our articles with @irisvanrooij.bsky.social and others are collected here too olivia.science/ai
Critical AI
On this page are some resources for Critical AI Literacy (CAIL) from my perspective.
olivia.science
November 14, 2025 at 4:22 PM
Reposted by Riccardo Capecchi
annaciaunica.bsky.social
www.nature.com/articles/s41...
Time, space, memory and brain–body rhythms - Nature Reviews Neuroscience
Understanding how the brain represents experienced time and how representations of space and time are integrated to form episodic memories has been a goal of much neuroscientific research. In this Per...
www.nature.com
November 14, 2025 at 5:51 AM
Reposted by Riccardo Capecchi
bmhdeen.bsky.social
Thrilled that this work is (finally) out! We argue that the human brain contains parallel systems for understanding people and places.

www.pnas.org/doi/10.1073/... 1/
November 11, 2025 at 10:20 PM
Reposted by Riccardo Capecchi
pessoabrain.bsky.social
𝗜𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗮 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 𝗻𝗲𝘁𝘄𝗼𝗿𝗸?
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
November 10, 2025 at 6:14 PM
Reposted by Riccardo Capecchi
broadwaybabyto.bsky.social
Before ACA, many Americans couldn’t afford insurance

Alex Smith was a diabetic who got kicked off his Mom’s insurance at 26

He made 35k a year which was “too much” for Medicaid, but not nearly enough to cover insurance premiums

He had to ration his insulin & died a month after losing insurance
Insulin's High Cost Leads To Lethal Rationing
Alec Raeshawn Smith was 23 when diagnosed with Type 1 diabetes and 26 when he died. He couldn't afford $1,300 per month for his insulin and other diabetes supplies, so he tried to stretch the doses.
www.npr.org
November 10, 2025 at 5:01 AM
Reposted by Riccardo Capecchi
quantamagazine.bsky.social
Earlier this year, we released a special issue titled “The Unraveling of Space-Time.” We cover black holes, holograms, and “alien algebra.” Explore the series:
The Unraveling of Space-Time | Quanta Magazine
This special issue of Quanta Magazine explores the ultimate scientific quest: the search for the fundamental nature of reality.
www.quantamagazine.org
November 9, 2025 at 9:04 PM
Reposted by Riccardo Capecchi
biblioraptorphd.bsky.social
I have somehow never read Breakfast of Champions and holy hell in three pages Vonnegut sums it all up - colonialism, racism, income inequality, and a guy who owns a car dealership who reads a scifi novel and takes away the wrong idea
The teachers told the children that this was when their continent was discovered by human beings. Actually, millions of human beings were already living full and imaginative lives on the continent in 1492. That was simply the year in which sea pirates began to cheat and rob and kill them. Actually, the sea pirates who had the most to do with the creation of the new government owned human slaves. They used human beings for machinery, and, even after slavery was eliminated, because it was so embarrassing, they and their descendants continued to think of ordinary human beings as machines. • The sea pirates were white. The people who were already on the continent when the pirates arrived were copper-colored. When slavery was introduced onto the continent, the slaves were black. Color was everything. tonster. Here was the core of the bad ideas which Trout gave to Dwayne: Everybody on Earth was a robot, with one exception-Dwayne Hoover. Of all the creatures in the Universe, only Dwayne was thinking and feeling and worrying and planning and so on. Nobody else knew what pain was. Nobody else had any choices to make. Everybody else was a fully automatic machine, whose purpose was to stimulate Dwayne. Dwayne was a new type of creature being tested by the Creator of the Universe. Only Dwayne Hoover had free will. Trout did not expect to be believed. He put the bad ideas into a science-fiction novel, and that was where Dwayne found them. The book wasn't addressed to Dwayne alone. Trout had never heard of Dwayne when he wrote it. It was addressed to anybody who happened to open it up. It said to simply anybody, in effect, "Hey-guess what: You're the only creature with free will. How does that make you feel?" And so on. It was a tour de force. It was a jeu d'esprit. But it was mind poison to Dwayne.
November 8, 2025 at 5:40 PM
Reposted by Riccardo Capecchi
financialtimes.com
Breaking news: US stocks have dropped as jitters over highly elevated valuations for many artificial intelligence companies intensified and top Wall Street executives said markets were vulnerable to a pullback. on.ft.com/4hIMmhj
November 4, 2025 at 9:12 PM
Reposted by Riccardo Capecchi
40percentgerman.bsky.social
"A good way to learn German is to read children's books to familiarise yourself with basic grammar and vocabulary"

German children's book:
December 10, 2024 at 6:58 AM
Reposted by Riccardo Capecchi
carpenterlab.bsky.social
We are excited to share our recent results on a new lncrna that functions to regulate proliferation in thp1 cells. This is the thesis work of Christy Montano.
biorxivpreprint.bsky.social bioRxivpreprint @biorxivpreprint.bsky.social · Oct 31
CRISPRi Screen Identifies a Novel Growth Suppressor lncRNA, INSTAR, in Human Monocytes https://www.biorxiv.org/content/10.1101/2025.10.30.685589v1
November 2, 2025 at 12:57 AM
Reposted by Riccardo Capecchi
jkagan1.bsky.social
An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense.
@cedarssinai.bsky.social
rdcu.be/eNIFY
Phagocytosis: a process that shapes immune responses to engulfed meals
Nature Reviews Immunology - In this Review, Li and Underhill discuss recent advances in understanding the process of phagocytosis. The authors highlight how phagocytosis is integral for innate...
rdcu.be
October 31, 2025 at 7:22 PM
Reposted by Riccardo Capecchi
castltrastondrs.bsky.social
#Medssky🧪 #IDsky #immunosky #Publichealth The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vaccination.
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses
The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vac…
www.sciencedirect.com
October 27, 2025 at 5:14 AM
Reposted by Riccardo Capecchi
manlius.bsky.social
A microscopic organism can survive the vacuum of space: yet our infrastructures collapse under a summer storm.

Why? 👉 Because structure isn’t enough.
Resilience depends on functionality.

And we need a lot of network science to grasp it.

📖 manlius.substack.com/p/making-sen...

#ComplexityThoughts
Making sense of complex systems functionality
What slime molds, neural systems and quantum physics have in common?
manlius.substack.com
October 26, 2025 at 9:34 AM
Reposted by Riccardo Capecchi
castltrastondrs.bsky.social
#Medsky🧪 #IDsky #Neurosky #Immunosky #publichealth Studies in 🐁 & 33 AD patients . The researchers suggests that brain cholesterol deficiency can significantly contribute to the initiation & progression of #Alzheimer’sdisease (AD).
Highlights Schematic summary of the molecular mechanism underlying DHCR24 knockdown-induced cognitive dysfunction mediated by the cGAS-STING signaling pathway.
October 26, 2025 at 5:08 AM