Stephen Royle
@steveroyle.bsky.social
I'm into chord changes and cell biology.
Professor - University of Warwick. Director - The Company of Biologists. Views are my own and not those of any organisation I am associated with.
Mastodon: @[email protected]
Lab: https://roylelab.org
Professor - University of Warwick. Director - The Company of Biologists. Views are my own and not those of any organisation I am associated with.
Mastodon: @[email protected]
Lab: https://roylelab.org
Reposted by Stephen Royle
Didn't realize Gipi (Giampietro Schiavo) was Neuro Editor @jcellsci.bsky.social longer than I have had a lab...: journals.biologists.com/jcs/article/...
Interview with Professor Giampietro Schiavo
ABSTRACT. Giampietro Schiavo is a Professor of Cellular Neuroscience, Deputy Director for strategy at Queen Square Institute of Neurology, academic lead of the Alzheimer Research UK Drug Discovery Ins...
journals.biologists.com
November 23, 2025 at 2:20 AM
Didn't realize Gipi (Giampietro Schiavo) was Neuro Editor @jcellsci.bsky.social longer than I have had a lab...: journals.biologists.com/jcs/article/...
Reposted by Stephen Royle
Did you know that @jcellsci.bsky.social has a new editor for neuronal cell biology? It's that guy @roylab-ucsd.bsky.social, I've heard good things about him
Interview with Journal of Cell Science Editor Subhojit Roy
ABSTRACT. Subhojit Roy is Professor of Pathology at the University of California San Diego (UCSD) in the USA. Subhojit completed his MD in Kolkata, India and then moved to Temple University in Philade...
journals.biologists.com
November 24, 2025 at 4:14 PM
Did you know that @jcellsci.bsky.social has a new editor for neuronal cell biology? It's that guy @roylab-ucsd.bsky.social, I've heard good things about him
Reposted by Stephen Royle
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
November 23, 2025 at 1:51 AM
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Not just fraud in papers, think about the antibody company datasheets...
Finally the scary example. The image of a western blot with a time course experiment, staining a protein of interest, showing the increase of protein over time and a second staining with a control antibody that does not change over time
November 21, 2025 at 2:46 PM
Not just fraud in papers, think about the antibody company datasheets...
Reposted by Stephen Royle
The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
November 21, 2025 at 1:07 PM
The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Reposted by Stephen Royle
Why IDPs Are Poor Candidates for Homotypic LLPS
🧵👇A thread
🧵👇A thread
November 20, 2025 at 6:32 PM
Why IDPs Are Poor Candidates for Homotypic LLPS
🧵👇A thread
🧵👇A thread
Reposted by Stephen Royle
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
November 21, 2025 at 3:54 AM
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
Reposted by Stephen Royle
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
Reposted by Stephen Royle
Know the difference.
November 19, 2025 at 10:08 PM
Know the difference.
Reposted by Stephen Royle
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
November 19, 2025 at 5:48 AM
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
For any PB-chasers interested in using data science to pick the best Marathon event. #RStats #running
quantixed.org/2025/11/17/c...
quantixed.org/2025/11/17/c...
Choose Your Fighter: data-driven selection of the best marathon – quantixed
quantixed.org
November 18, 2025 at 1:33 PM
For any PB-chasers interested in using data science to pick the best Marathon event. #RStats #running
quantixed.org/2025/11/17/c...
quantixed.org/2025/11/17/c...
Reposted by Stephen Royle
New from Mishima & Balasubramanian (@sporemohan.bsky.social) labs in @warwickmed.bsky.social: “Actin arginylation alters myosin engagement & F-actin patterning despite structural conservation.” Explore the physiology of #arginylated #actin 👉 rupress.org/jcb/article/...
Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation | Journal of Cell Biology | Rockefeller University Press
Actin is vital for cell functions and is regulated by posttranslational modifications like arginylation. The structure of arginylated β-actin (R-β-actin) i
rupress.org
November 14, 2025 at 9:09 PM
New from Mishima & Balasubramanian (@sporemohan.bsky.social) labs in @warwickmed.bsky.social: “Actin arginylation alters myosin engagement & F-actin patterning despite structural conservation.” Explore the physiology of #arginylated #actin 👉 rupress.org/jcb/article/...
Reposted by Stephen Royle
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:24 AM
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Reposted by Stephen Royle
ICYMI - In September, we co-hosted a mini-symposium with the Membrane Trafficking webinar series. You can view the recordings of the talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and the keynote lecture from Gillian Griffiths @griffithslab.bsky.social.
FocalPlane features... membrane trafficking recordings - FocalPlane
FocalPlane features... membrane trafficking recordings - News
focalplane.biologists.com
November 14, 2025 at 2:33 PM
ICYMI - In September, we co-hosted a mini-symposium with the Membrane Trafficking webinar series. You can view the recordings of the talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and the keynote lecture from Gillian Griffiths @griffithslab.bsky.social.
There's a paper that I am sure exists but I cannot find it via searching. Starting to wonder if I imagined it. Who needs LLMs to hallucinate references when I can do it all by myself?
#LifeOfPI
#LifeOfPI
November 13, 2025 at 1:44 PM
There's a paper that I am sure exists but I cannot find it via searching. Starting to wonder if I imagined it. Who needs LLMs to hallucinate references when I can do it all by myself?
#LifeOfPI
#LifeOfPI
Reposted by Stephen Royle
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Applications for ERC Synergy Grants 2026: Facts and figures
The ERC Synergy Grants 2026 call closed for applications on 5 November 2025. These are the preliminary data on the submitted proposals:
erc.europa.eu
November 11, 2025 at 1:22 PM
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Reposted by Stephen Royle
Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.
Induced protein proximity offers powerful new routes to modulate protein fate. While proteolysis-targeting chimeras (PROTACs) promote degradation through E3 ligase recruitment, the converse principle-...
www.biorxiv.org
November 10, 2025 at 4:34 PM
Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Stephen Royle
📢 Enhance your bioimage analysis skills - 2-day hands-on napari workshop.
Learn to:
- Set up conda envis install napari
- Navigate napari GUI install plugins
- Jupyter notebooks for basic IA
- Apply new skills to real datasets w expert guidance
📅 Apply by NOW!
www.crick.ac.uk/whats-on/cbi...
Learn to:
- Set up conda envis install napari
- Navigate napari GUI install plugins
- Jupyter notebooks for basic IA
- Apply new skills to real datasets w expert guidance
📅 Apply by NOW!
www.crick.ac.uk/whats-on/cbi...
CBIAS napari workshop 2025
www.crick.ac.uk
November 7, 2025 at 10:49 AM
📢 Enhance your bioimage analysis skills - 2-day hands-on napari workshop.
Learn to:
- Set up conda envis install napari
- Navigate napari GUI install plugins
- Jupyter notebooks for basic IA
- Apply new skills to real datasets w expert guidance
📅 Apply by NOW!
www.crick.ac.uk/whats-on/cbi...
Learn to:
- Set up conda envis install napari
- Navigate napari GUI install plugins
- Jupyter notebooks for basic IA
- Apply new skills to real datasets w expert guidance
📅 Apply by NOW!
www.crick.ac.uk/whats-on/cbi...
Reposted by Stephen Royle
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Stephen Royle
Publishers being very naughty with retractions...
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
November 6, 2025 at 3:59 PM
Publishers being very naughty with retractions...
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
I'd only dabbled with napari, but needed to use it for a paper we're writing. This is a quick post about getting started: from installation to a folder full of thousands of processed images, with gotchas along the way.
quantixed.org/2025/11/04/a...
quantixed.org/2025/11/04/a...
Adventures in Code VII: getting started with napari – quantixed
quantixed.org
November 4, 2025 at 10:00 AM
I'd only dabbled with napari, but needed to use it for a paper we're writing. This is a quick post about getting started: from installation to a folder full of thousands of processed images, with gotchas along the way.
quantixed.org/2025/11/04/a...
quantixed.org/2025/11/04/a...
Reposted by Stephen Royle
In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.
November 4, 2025 at 1:41 AM
In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.
Reposted by Stephen Royle
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!