Lightnews — Scholar-powered news

Pedro Friedmann Angeli @angelifriedmann.bsky.social · 9h

This is madness...
pure madness
www.theguardian.com/world/ng-int...

Young lives cut short on an unimaginable scale: the 18,457 children on Gaza’s list of war dead

Every name on a list compiled by health authorities in Gaza of the child victims of Israel’s offensive

www.theguardian.com

Reposted by Pedro Friedmann Angeli

Humboldt-Stiftung @humboldt-foundation.de · 1d

✨✨✨ Huge congratulations to the winners of the #NobelPrize in Physics: John Clarke, Michel H. Devoret and John M. Martinis. Clarke and Martinis are both members of the Humboldt Network – as hosts for Feodor Lynen Research Fellows! 💚

Picture: Ill. Niklas Elmehed © Nobel Prize Outreach

Three drawn portraits of men – the Nobel Prize winners in physics in 2025

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Pedro Friedmann Angeli @angelifriedmann.bsky.social · 1d

only resubmit

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Pedro Friedmann Angeli @angelifriedmann.bsky.social · 4d

www.theguardian.com/world/2025/o...

will be too late when people realise that is not about left and right

‘One rule for the rich’: the Salzburg mansion, the Porsche heir and the writer Stefan Zweig

The car magnate, who is restoring the Jewish author’s former villa, has been given permission to dig out a 500-metre road leading to a garage, causing consternation in the city

www.theguardian.com

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Reposted by Pedro Friedmann Angeli

Lisa Heinke @lisaheinke.bsky.social · 8d

Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:

Ishier Raote @ishier.bsky.social · 8d

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...

Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology

Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

www.nature.com

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Reposted by Pedro Friedmann Angeli

Pedro Friedmann Angeli @angelifriedmann.bsky.social · Aug 6

🚨Preprint alert 🚨

We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.

www.biorxiv.org/content/10.1....

pls check @olzmannlab.bsky.social

www.biorxiv.org/content/10.1...

#ferroptosis #FSP1 #antioxidants

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

www.biorxiv.org

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Reposted by Pedro Friedmann Angeli

Pedro Friedmann Angeli @angelifriedmann.bsky.social · 12d

very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this

Live-cell imaging with fluorogenic radical-trapping antioxidant probes reveals the onset and progression of ferroptosis - Nature Chemistry

Spatiotemporal information on ferroptosis progression is highly desired to develop new therapies. Now, the development of organelle-targeting fluorogenic radical-trapping antioxidants has enabled dissection of the dynamic subcellular evolution of ferroptosis through real-time live-cell fluorescence imaging.

www.nature.com

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Pedro Friedmann Angeli @angelifriedmann.bsky.social · 12d

very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this

Live-cell imaging with fluorogenic radical-trapping antioxidant probes reveals the onset and progression of ferroptosis - Nature Chemistry

Spatiotemporal information on ferroptosis progression is highly desired to develop new therapies. Now, the development of organelle-targeting fluorogenic radical-trapping antioxidants has enabled dissection of the dynamic subcellular evolution of ferroptosis through real-time live-cell fluorescence imaging.

www.nature.com

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Pedro Friedmann Angeli @angelifriedmann.bsky.social · 12d

meteoroptosis

Daniel Drucker @danieljdrucker.bsky.social · 12d

A therapeutically targetable pathway promoting MASH fibrosis involving a non-apoptotic function of caspase-8 and a newly discovered HSC activator, meteorin.
www.nature.com/articles/s42...

A non-apoptotic caspase-8–meteorin pathway in hepatocytes promotes MASH fibrosis - Nature Metabolism

Hepatocyte caspase-8 in MASH promotes the activation of hepatic stellate cells and liver fibrosis through an apoptosis-independent mechanism

www.nature.com

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Reposted by Pedro Friedmann Angeli

Max-Planck-Gesellschaft @maxplanck.de · 23d

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Graphic with a blue background and light green dots. The text 'call for applications' appears in green, and 'Ausschreibung' in white. A white arrow on the right points diagonally upward.

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Pedro Friedmann Angeli @angelifriedmann.bsky.social · 26d

Preach freedom of speech overseas, but ignore that weak institutions are what give clowns the spotligh

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Reposted by Pedro Friedmann Angeli

André Nadler @nadlerlab.bsky.social · 28d

This is an really amazing opportunity. If you get it, you can essentially pick you institute. The package really is rather competitive.

Max-Planck-Gesellschaft @maxplanck.de · 29d

Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer

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Reposted by Pedro Friedmann Angeli

Emmanuel Saliba @emmanuel-saliba.bsky.social · 28d

🔔PhD position open. Interested in building competencies in computational biology in spatial transcriptomics? Malte Luecken's lab and I have an open PhD position, part of the Munich School of Data Science.
Application deadline: Sept 26
Link: www.mu-ds.de

MUDS - Helmholtz Information & Data Science Academy

www.mu-ds.de

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Reposted by Pedro Friedmann Angeli

Bettina Böttcher @boettchercryoem.bsky.social · Aug 29

🧪❄️🔬
We were very surprised to find out that the MscS-like channel YnaI does not tilt its paddle helices to open.... almost overlooked the huge pore in our cryo-EM maps
Very proud that this is finally out: rdcu.be/eB3FF
Well done, Vanessa @uni-wuerzburg.de

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Reposted by Pedro Friedmann Angeli

Markus Elsner @markuselsner.bsky.social · Aug 28

uuhh, wohl keine Müller Milch für mich mehr 🤮

Ann-Katrin Müller @akm0803.bsky.social · Aug 28

Molkerei-Milliardär Theo Müller ist mit AfD-Chefin Alice Weidel befreundet. So eng, dass er sie zu seiner pompösen Geburtstagsfeier Ende Mai einlud. Es waren noch andere extreme Rechte da - genauso wie gut vernetzte Wirtschaftsleute sowie Vertreter demokratischer Parteien. Unsere neue Recherche:

(S+) Unternehmer Theo Müller und seine Gäste: Ziemlich rechtsextreme Freunde

Der Molkerei-Milliardär Theo Müller ist mit AfD-Chefin Alice Weidel befreundet. So eng, dass er sie zu seiner pompösen Geburtstagsfeier einlud. Nicht als Einzige vom politischen Rand, wie SPIEGEL-Rech...

www.spiegel.de

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Reposted by Pedro Friedmann Angeli

eLife @elife.bsky.social · Aug 23

Membrane Biology: Nothing can replace polyunsaturated lipids

Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN

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Reposted by Pedro Friedmann Angeli

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · Aug 19

SLC26A11 is an atypical solute carrier with dual transport-channel function mediating lysosomal sulfate transport https://www.biorxiv.org/content/10.1101/2025.08.17.670773v1

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Reposted by Pedro Friedmann Angeli

Garry Kasparov @garrykasparov.bsky.social · Aug 22

By the way, if you don't protest Trump weaponizing the Justice Department against his critics because they are people you don't like or agree with, you are assisting this fascist takeover. Wait until it happens to someone you like and it's too late.

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Reposted by Pedro Friedmann Angeli

André Nadler @nadlerlab.bsky.social · Aug 21

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

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Reposted by Pedro Friedmann Angeli

Hart @hart-frentz.bsky.social · Aug 19

Können wir bitte zuerst die Bahn sanieren 🫢

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Reposted by Pedro Friedmann Angeli

André Nadler @nadlerlab.bsky.social · Aug 10

This. @erc.europa.eu, this is the way to go!

paveltomancak.bsky.social @paveltomancak.bsky.social · Aug 10

Looks like private funders, HHMI,CZI etc., are not going to “save” US research. Europe is setting up mechanisms to attract US researchers & it may work. But, common, target junior talent, don’t shower money on superstars who will be flying professors & return to US when the science winter passes.

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Reposted by Pedro Friedmann Angeli

Harvard Molecular Metabolism @met-hsph.bsky.social · Aug 8

Jessalyn Ubellacker @ubellackerlab.bsky.social was honored with a FASEB Journal Early Career Researcher Award at the first FASEB Ferroptosis, Oxidative Stress, and Lipid Metabolism meeting, co-organized by James Olzmann @olzmannlab.bsky.social and Scott Dixon, to support early career researchers.

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Reposted by Pedro Friedmann Angeli

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · Aug 7

Don't miss out on other great Review content!
📝 A Review from @angelifriedmann.bsky.social, @k-hadian.bsky.social, et al details the metabolic code of ferroptosis
📝 @damelab.bsky.social et al describe how prokaryotes and viruses possess histone-mediated chromatin organization

(1/n)

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Pedro Friedmann Angeli @angelifriedmann.bsky.social · Aug 7

congrats James! 👍👍

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Reposted by Pedro Friedmann Angeli

James Olzmann @olzmannlab.bsky.social · Aug 6

Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis

Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...

www.biorxiv.org

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