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Felix Campelo @felixmendu.bsky.social · 9d

Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio

Felix Campelo @felixmendu.bsky.social · Jul 4

Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio

meetings.embo.org/event/26-org...

Intracellular mechanics and organelle mechanobiology

Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…

meetings.embo.org

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UK Dementia Research Institute @ukdri.ac.uk · 9d

Researchers led by Prof Jernej Ule (@ulelab.bsky.social)
have discovered a new biological process that they’ve called ‘interstasis’ - a way for cells to keep groups of proteins in check💡

The team are now exploring the role of interstasis in neurodegeneration ⬇️ www.crick.ac.uk/news/2025-09...

Better together: researchers discover how cells keep groups of proteins in check

Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...

www.crick.ac.uk

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Avezov lab @avezovlab.bsky.social · Jul 28

Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF
www.biorxiv.org/content/10.1...

and MANF before www.nature.com/articles/s41...

www.biorxiv.org

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Eric Chevet @ericchevet.bsky.social · Jul 28

and the reverse is also true ... factors believed to exert their functions inside playing roles outside ....

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Avezov lab @avezovlab.bsky.social · Jul 28

Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF
www.biorxiv.org/content/10.1...

and MANF before www.nature.com/articles/s41...

www.biorxiv.org

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Eric Chevet @ericchevet.bsky.social · Jul 20

This week's selection of #preprints and articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

🗣️: 4 #preprints from
@qilabuva.bsky.social lab on SEL1L-HRD1 in ERAD
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...

bims-proteo 2025-07-20 papers

biomed.news

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PLOS Biology @plosbiology.org · Jul 11

#ER - #membrane contact sites are often distorted by existing labeling methods. @steveroyle.bsky.social &co present an inducible labeling system (LaBeRling) using #LaminB receptor to fluorescently tag ER-membrane contact sites in live cells, preserving morphology @plosbiology.org 🧪 plos.io/4lv6gxu

Left: LaBeRling contact sites between the plasma membrane (green) and the endoplasmic reticulum (magenta). Contacts are highlighted in blue using LBR. Image created by Laura Downie. Right: 3D render of a membrane contact site (orange) between a mitochondrion (pink) and the ER (green contours). Image created by Stephen Royle.

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Avezov lab @avezovlab.bsky.social · Jul 16

Check this out 👇fly sleep and organelle
morphology changes www.nature.com/articles/s41...

Mitochondrial origins of the pressure to sleep - Nature

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

www.nature.com

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Anupam Patgiri @apatgiri.bsky.social · Jul 11

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox www.science.org/doi/10.1126/...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox

Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...

www.science.org

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Science in Boston @scienceinboston.com · Jun 25

. @whiteheadinstitute.bsky.social researchers developed Perturb-Multimodal, a powerful new approach that simultaneously measures how genetic changes affect both #GeneExpression and cell structure in intact liver tissue.

📰: bit.ly/440TrVi
📝 @cellpress.bsky.social: bit.ly/3TEs2ST

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The Francis Crick Institute @crick.ac.uk · Jun 25

Researchers at the Crick and UCL have developed laboratory models of dementia, including Alzheimer's, to show that certain genetic messages are misplaced in diseased nerve cells.

The finding could offer a potential target for new treatments for neurodegeneration.

www.crick.ac.uk/news/2025-06...

Researchers identify lost genetic messages as a target for treating dementia

Researchers at the Francis Crick Institute and UCL have shown that genetic messages are misplaced in nerve cells in a model of Alzheimer’s disease and frontotemporal dementia.

www.crick.ac.uk

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Jenna Elliott @jennaelliott.bsky.social · Jun 18

🧵 🧪 1/ Hi! I’m excited to share our latest work, now on arXiv:

Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)

Where we explore how the physical properties of living systems can help cells process spatial information.

Sketch of membrane-enclosed compartment with particles on its surface, which interact with an adjacent structure

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Gabriele Corso @gcorso.bsky.social · Jun 6

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

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UK Dementia Research Institute @ukdri.ac.uk · Apr 30

Researchers led by @clairedurrant1.bsky.social have used living human brain tissue to show for the first time how a toxic protein in Alzheimer’s can damage synapses👏

The team hope the cutting-edge tool could help accelerate the development of new treatments👉 buff.ly/cXK2LIa

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Florent Waltz @florentwaltz.bsky.social · Apr 25

Check out the latest version of MemBrain, spearheaded by computation superstar @lorenzlamm.bsky.social ! It can segment, pick particles and give you metrics on everything!

Lorenz Lamm @lorenzlamm.bsky.social · Apr 25

🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo

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Rikki Garner @rikkigarner.bsky.social · Apr 24

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...

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Avezov lab @avezovlab.bsky.social · Apr 23

This is one to watch 🔬Congratulations!

Falk Schneider @faldalf.bsky.social · Apr 22

#newPI and time is running.

It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:

warwick.ac.uk/fac/sci/med/...

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Amir Rahmani @astormic.bsky.social · Apr 7

A room full of microscopy enthusiasts, Cambridge Microscopy Meeting 2025. #CMM2025

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Luke Lavis @rhodamine110.bsky.social · Apr 1

Honored to help enable two back-to-back papers in @natureneuro.bsky.social; first DELTA www.nature.com/articles/s41... with collaborators at @hhmijanelia.bsky.social and then EPSILON www.nature.com/articles/s41... with @adamezracohen.bsky.social; @dyerfulchymist.bsky.social is always in the mix!

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning - Nature Neuroscience

Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms underlying syna...

www.nature.com

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Katie Downes @dr-downes.bsky.social · Mar 25

I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.

Check it out here!
rdcu.be/eeY1J

#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES

Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway

Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...

rdcu.be

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Jonny Nixon-Abell @abelljonny.bsky.social · Mar 24

😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications

Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...

www.nature.com

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Alexey Amunts @amunts.bsky.social · Mar 22

github.com/ChatMol/mole...

GitHub - ChatMol/molecule-mcp: A model-context-protocol server for molecules.

A model-context-protocol server for molecules. Contribute to ChatMol/molecule-mcp development by creating an account on GitHub.

github.com

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HHMI @hhmi.org · Mar 22

This video, created by Andy Moore, a Research Scientist at @hhmijanelia.bsky.social, shows a cell w a dynamic network of endoplasmic reticulum (ER) tubules—present in every eukaryotic cell—as well as mitochondria migrating through the cell’s interior. The ER is orange, and the mitochondria are blue.

Energy on Demand #stem #stemeducation #shorts #science #DidYouKnow #YouTubeShorts #ShortsScience

YouTube video by Howard Hughes Medical Institute (HHMI)

www.youtube.com

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Cedric Feschotte @cedricfeschotte.bsky.social · Mar 17

🤯 cryo-ET of copia viral-like particles lurking at the nuclear pore of intact Drosophila eggs!
Amazing work by @svenklumpe.bsky.social & more cool findings in this collaborative paper illuminating the replication cycle of an iconic retrotransposon!
www.cell.com/cell/fulltex...

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Dave Barry @david-j-barry.bsky.social · Mar 17

Calling all...
🔬 Microscopists
💻 BioImage Analysts
👩‍🔬 Life Scientists

📅 Save the Date

The 5th edition of the Crick BioImage Analysis Symposium will take place on November 24/25th 2025.

More details to follow...

#CBIAS2025

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