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Reposted by Zoher Gueroui 🦠🔬

John Ngo @johntngo.bsky.social · 16d

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

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Sarah Cohen @cohenlaboratory.bsky.social · 21d

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

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Manuel Thery @manuelthery.bsky.social · 29d

Which city is the best for Cytoskeleton research?
Dresden? Barcelona? Cambridge ? Noooo ... you all know its Paris, right? 😎
Registering to the annual meeting on Friday 14th of November is now open:
pcd2025.sciencesconf.org
Keynote speeches by @carter-lab.bsky.social and Verena Ruprecht !

Paris Cytoskeleton Day 2025 - Sciencesconf.org

pcd2025.sciencesconf.org

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Zoher Gueroui 🦠🔬 @zgueroui.bsky.social · 29d

Big Thanks @lisaheinke.bsky.social and Nature Reviews Molecular Cell Biology @natrevmcb.nature.com for the opportunity for our students, Chems and Emma, to write a Tools of the Trade piece on our recently published ControLD technique.

Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · Aug 3

ICYMI: New Online! Condensate-mediated intracellular organelle sequestration

Condensate-mediated intracellular organelle sequestration

Nature Reviews Molecular Cell Biology, Published online: 31 July 2025; doi:10.1038/s41580-025-00880-xIn this Tools of the Trade article, Pasquier and Amari (Gueroui lab) describe the development of ControLD, which allows the intracellular sequestration of organelles through condensate formation, enabling the control of inter-organelle communication.

bit.ly

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Pablo J. Sáez @pjsaez.bsky.social · Jun 28

Do you know what happens if you squeeze a #cell?

If the #confinement is high, the nucleus (green) will be super tense & the compressed cells will react like this👇🏽changing their #cytoskeleton (magenta)

Full: www.science.org/doi/10.1126/...
#scicomm #microscopy #sciencesky @focalplane.bsky.social 🧪🔬

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Christophe 🔬 L @christlet.bsky.social · Jun 16

The 2025 @cnrs.fr medal are out! Bronze medals for early career researchers: congrats to Aurélie Tchoghandjian at our institute @inp-marseille.bsky.social, and to @alexandra-colin.bsky.social who was nominated by the Cell biology section 🎉

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Nature Chemical Biology @natchembio.nature.com · May 21

A condensate-based approach reversibly sequesters lipid droplets (LDs) in cells, temporarily halting their functions and enabling detailed study of LD biology and the interactions of LDs with other cellular structures

www.nature.com/articles/s41...

Controlling lipid droplet dynamics via tether condensates - Nature Chemical Biology

Amari et al. developed a condensate-based approach, named ControLD, for reversible trapping and release of lipid droplets inside living cells, temporarily halting their functions, enabling detailed st...

www.nature.com

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Zoher Gueroui 🦠🔬 @zgueroui.bsky.social · May 21

Thanks Benoit!

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Zoher Gueroui 🦠🔬 @zgueroui.bsky.social · May 21

Thanks Ebony!

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Zoher Gueroui 🦠🔬 @zgueroui.bsky.social · May 21

What if we could trap Lipid Droplets and control their dynamics in cells?
Our latest work does just that, using Engineered Condensates to manipulate LD behavior.
Exciting results by Chems Amari and the team!
Great collab with ‪@abdourachidthiam.bsky.social‬
#Organelles #Condensates

rdcu.be/emYpU

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Hyman Lab @hymanlab.bsky.social · May 14

Hiro's paper is out! @hiro-cg5445.bsky.social
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!

www.nature.com/articles/s41...

Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

www.nature.com

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James Olzmann @olzmannlab.bsky.social · May 7

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Lipid-degrading small molecule kills cancer cells by ferroptosis

A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

www.nature.com

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Shicheng Guo @shihcheng.bsky.social · Apr 30

Oligo-LiveFISH enables high-res, live imaging of non-repetitive DNA loci in 3D across cell types, overcoming past limitations in dynamic genome studies. PMID:40239646, Cell 2025, @Cell https://www.cell.com/cell/fulltext/S0092-8674(25)00350-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://www.cell.com/cell/fulltext/S0092-8674(25)00350-2

No description available

www.cell.com

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Ben Sabari @bsabari.bsky.social · Apr 25

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....

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Job Boekhoven @boekhovenlab.bsky.social · Apr 25

How can a cell control the size of its organelles?

Excited to share a mechanism to control droplet size we recently found.

a 🧵

www.nature.com/articles/s41...

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Laboratory of Genomic Stability @lgs-imb.bsky.social · Apr 7

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...

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adamezracohen.bsky.social @adamezracohen.bsky.social · Mar 31

Which synapses get stronger when we form a memory? We developed a technique to tag recently potentiated synapses in live mice. Pulse-chase labeling with membrane-impermeable HaloLigand dyes distinguishes fresh AMPA receptors from old ones. www.nature.com/articles/s41...

EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation - Nature Neuroscience

Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA receptor exocytosis and ...

www.nature.com

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CPCV @cpcv.bsky.social · Mar 25

Very happy to share the recent paper of Lina El Hajji in Arnaud
Gautier's team on the development of a tunable chemogenetic
near-infrared fluorescent reporter for imaging proteins in live cells and organisms
www.nature.com/articles/s41...

A tunable and versatile chemogenetic near-infrared fluorescent reporter - Nature Communications

This paper reports the engineering of nirFAST, a near-infrared fluorescent chemogenetic reporter suitable for multi-color protein imaging in cells and organisms, as well as for the design of cellular ...

www.nature.com

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Gladfelter Lab @gladfelterlab.bsky.social · Mar 19

Excited to share our first story on nuclear paraspeckles! Led by @sneadlab.bsky.social, this is the culmination of a ~4 year effort in collab. with @shrinivaslab.bsky.social. Can’t wait to see more paraspeckle stories from the future Snead Lab at Northwestern 🫧 www.biorxiv.org/content/10.1...

Immiscible proteins compete for RNA binding to order condensate layers

Biomolecular condensates mediate diverse and essential cellular functions by compartmentalizing biochemical pathways. Many condensates have internal subdomains with distinct compositional identities. ...

www.biorxiv.org

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Cell Biology J-Club @cellclub.bsky.social · Mar 15

Axonal RNA localization is essential for long-term memory
www.nature.com/articles/s41...

Axonal RNA localization is essential for long-term memory - Nature Communications

Axonal transcriptomes have been characterized, but their regulation and role in neuronal circuits remain unclear. Here authors uncover activity-dependent RNA localization in axons important for memory...

www.nature.com

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Nott Lab @nottlab.bsky.social · Mar 17

New paper out! Why do condensates prefer some surfaces and not others? Check it out here: doi.org/10.1063/5.02...

Intrinsic hydrophobicity of IDP-based biomolecular condensates drives their partial drying on membrane surfaces

The localization of biomolecular condensates to intracellular membrane surfaces has emerged as an important feature of sub-cellular organization. In this work,

doi.org

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Di Jiang @dijiang319.bsky.social · Mar 13

@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/...
#RNAsky #RNAbiology #Cryo-EM

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Sebastian von Haaren @haarensv.bsky.social · Mar 13

A small but special moment: My illustration is on the cover of the March issue of Nature Methods!

A huge hug to @anwaiarchit.bsky.social and @cppape.bsky.social — it was a pleasure to work alongside you on this!

www.nature.com/nmeth/volume...

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SCF ChemBio @scf-chembio.bsky.social · Feb 18

The SCF-ChemBio Thesis Award has been granted to Lina El Hajji (@linaelhajji.bsky.social) for her outstanding doctoral work under the supervision of Arnaud Gautier in the Laboratoire des Biomolécules (now Chimie Physique et Chimie du Vivant), Paris ! Congratulations! 👏
#ChemBio

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Boris Vauzeilles @borisvauzeilles.bsky.social · Feb 13

Do not miss the exceptional #ChemBio lineup of PSL Chemical Biology Symposium 2025 in Paris, @institutcurie.bsky.social - February 27-28 - Last 2 days to register!!! #ChemBioLovers

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