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Reposted by Francesco Scavone

Elodie Lafont @elodie-lafont.bsky.social · 16d

Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social.
https://doi:10.1111/febs.70259
The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR

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Francesco Scavone @fscavone.bsky.social · 19d

Congrats David! Looking forward to read it.

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Reposted by Francesco Scavone

David Balchin @davidbalchin.bsky.social · 19d

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology

By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...

www.nature.com

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Reposted by Francesco Scavone

American Society for Cell Biology @ascbiology.bsky.social · 28d

From MBoC... Dr. Francesco Scavone (Stanford) shows ATG9A has an unexpected role in trafficking K63-polyubiquitin–modified membrane proteins. Blocking the signal traps cargos in vesicle clusters; once released, they rapidly reach lysosomes. 🔗 www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology

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Reposted by Francesco Scavone

Elias Adriaenssens @elias-adriaenssens.bsky.social · Aug 13

Absolutely honoured to see our work featured on this month’s cover! 🎉🧬

Artwork by the incredibly talented @doroteaartscience.bsky.social 👇

Nature Cell Biology @natcellbio.nature.com · Aug 12

🏖️Our August issue's out!
Cover: Flexibility of #autophagy initiation

👉🏼Review on #metabolism in #embryogenesis #devbio
👉🏼Review on #DNArepair
🔬 #ribosomes #neurodevelopment #mitophagy #ferroptosis #stemcells #epigenetics #leukemia #antitumor immunity & more!
www.nature.com/ncb/volumes/...

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Reposted by Francesco Scavone

Böke Lab @bokelab.bsky.social · Jul 18

Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature.
👇 for @zaffagg3 's detailed explanation

www.embopress.org/doi/full/10....

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Reposted by Francesco Scavone

Karolin Luger @nucleosomepolice.bsky.social · Jul 17

#cryoEM confluence in Munich #womeninSTEM

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Reposted by Francesco Scavone

Karolin Luger @nucleosomepolice.bsky.social · Jun 27

new preprint alert from the lab: bringing some order into the wide and wild diversity of archaeal histones. Who has acidic histones? who has multiple histones? what histone combinations do archaea employ and why? find all of this and more here
www.biorxiv.org/content/10.1...

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Reposted by Francesco Scavone

Jim Hurley @jimhurley.bsky.social · Jun 25

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

The expanding repertoire of ESCRT functions in cell biology and disease - Nature

This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.

tinyurl.com

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Reposted by Francesco Scavone

Ahmad Jomaa @jomaalab.bsky.social · Jun 16

Check out our latest preprint with the Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: www.biorxiv.org/content/10.1...

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Francesco Scavone @fscavone.bsky.social · Jun 15

Highlight on our recent work on UFMylation by @dimitristypas.bsky.social on @NatureSMB: www.nature.com/articles/s41...

UFMylation-dependent quality control of ER-stalled ribosomes - Nature Structural & Molecular Biology

Nature Structural & Molecular Biology - UFMylation-dependent quality control of ER-stalled ribosomes

www.nature.com

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Reposted by Francesco Scavone

Sonya Neal @neal-lab.bsky.social · Jun 12

Huge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social

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Reposted by Francesco Scavone

Francesca Mattiroli @fmattiroli.bsky.social · Jun 12

We are excited to get on this project and learn more about chromatin organization! Great to share this good news with Ina and Matilde, congrats everyone!

Hubrecht Institute @hubrechtinstitute.bsky.social · Jun 12

Congratulations to group leaders Matilde Galli, Ina Sonnen, and Francesca Mattiroli on receiving M-grants from the Dutch Research Council (NWO)! 🎉
With this funding, they’ll explore cell division, gut cell communication and DNA packaging.
Read more here 👉 www.hubrecht.eu/nwo-m-grants...

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Reposted by Francesco Scavone

James Olzmann @olzmannlab.bsky.social · May 29

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
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Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS

FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

www.pnas.org

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Reposted by Francesco Scavone

Amit Joshi @joshilaboratory.bsky.social · May 23

Excited to present first publication from the Joshi lab, now in @jcb.org

Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain.

rupress.org/jcb/article/...

Phosphatidic acid drives spatiotemporal distribution of Pex30 at ER-LD contact sites | Journal of Cell Biology | Rockefeller University Press

In this study, we show that Pex30 dysferlin domain binds PA through its two hydrophobic regions adjacent to beta sheets. We propose that, PA, a precursor f

rupress.org

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Reposted by Francesco Scavone

MolinariLab-ER @molinarilab-er.bsky.social · May 22

Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing.
N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...

N-glycan-dependent protein maturation and quality control in the ER - Nature Reviews Molecular Cell Biology

N-glycosylation of secretory pathway proteins in the ER is crucial for their maturation and quality control. Recent insights into the enzymes and chaperones that facilitate N-glycosylation have expand...

www.nature.com

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Francesco Scavone @fscavone.bsky.social · May 2

New paper from our lab! 🥳🎉 "UFMylation orchestrates spatiotemporal coordination of RQC at the ER"
@Science Advances
www.science.org/doi/10.1126/...

UFMylation orchestrates spatiotemporal coordination of RQC at the ER

Structures of stalled ER-bound 60S ribosomal subunits identify cooperative interaction between UFMylation and RQC machineries.

www.science.org

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Reposted by Francesco Scavone

James Olzmann @olzmannlab.bsky.social · Apr 26

Happy to have contributed in a small way to this exciting study from Daniel Nomura identifying a new covalent degrader handle that acts through the dcaf16 E3 ligase! 🤩

Dan Nomura @dannomura.bsky.social · Apr 26

Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders.

www.biorxiv.org/content/10.1...

DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders

Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, th...

www.biorxiv.org

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Francesco Scavone @fscavone.bsky.social · Apr 25

Congrats!

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Reposted by Francesco Scavone

Hemmo Meyer Lab @hemmo-lab.bsky.social · Apr 23

We are looking for a PhD student with interest in protein biochemistry on a really cool project “Cooperation of deubiquitinating enzymes and VCP/p97 in cellular stress responses”. Build your own reactions! fully funded. apply with code 193-25. #ubiquitin

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Roberto Zoncu Lab @robzonculab.bsky.social · Apr 23

Our PKA-autophagy story by outstanding graduate student Ashley Segura (co-led with Rose Citron) published in @embojournal.org, dissects a deep connection between autophagy and PKA in neuronal signaling, with implications for neurological disease. Great collaboration with @manciaslab.bsky.social!

The EMBO Journal @embojournal.org · Apr 22

AKAP11 recruits PKA holoenzymes to #autophagosomes in a bidirectional functional association, both promoting downstream PKA signaling and increasing AKAP11-PKA complex degradation
@robzonculab.bsky.social @ucberkeleyofficial.bsky.social
www.embopress.org/doi/full/10....

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Reposted by Francesco Scavone

De Camilli Lab @pdc-lab.bsky.social · Apr 10

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage

Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

rdcu.be

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Francesco Scavone @fscavone.bsky.social · Apr 13

Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit

www.pnas.org/doi/abs/10.1...

Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | PNAS

The integrated stress response (ISR) is a central signaling network that enables eukaryotic cells to respond to a variety of different environmenta...

www.pnas.org

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Francesco Scavone @fscavone.bsky.social · Apr 13

Highly conserved ribosome biogenesis pathways between human and yeast revealed by the MDN1-NLE1 interaction and NLE1 containing pre-60S subunits

academic.oup.com/nar/article/...

Highly conserved ribosome biogenesis pathways between human and yeast revealed by the MDN1-NLE1 interaction and NLE1 containing pre-60S subunits

Abstract. The assembly of ribosomal subunits, primarily occurring in the nucleolar and nuclear compartments, is a highly complex process crucial for cellul

academic.oup.com

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Reposted by Francesco Scavone

Elif Karagöz @gekaragoz.bsky.social · Apr 7

Check out our new preprint, in which brilliant @alessandrick.bsky.social‬ revealed a novel function of the RNA-binding protein IGF2BP3 in regulating the unfolded protein response. Please see the wonderful thread by @alessandrick.bsky.social‬ for more detail! www.biorxiv.org/content/10.1...

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