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Reposted by Estefania Sanchez-Vasquez

Ricard Solé @ricardsole.bsky.social · 8h

How does life construct itself from within, and how might we learn to emulate its generative logic? Glad to be soon talking and discussing with @philipcball.bsky.social @bertaverd.bsky.social and other great colleagues at this @royalsociety.org event royalsociety.org/science-even...

Generative biology: new approaches to study developmental design principles | Royal Society

Theo Murphy meeting organised by Dr Jake Cornwall-Scoones, Dr Dirk Benzinger, and Professor Sally Lowell.

royalsociety.org

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Rodrigo Fernandez-Gonzalez @rodrigofg.bsky.social · Nov 11

A quick re-intro: we are interested in the mechanisms of collective cell behaviour, particularly cell movement. We use fly embryos, quantitative microscopy, image analysis and computer-based modelling. One of the systems where we study collective cell movement is the wound healing response.

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Miki Ebisuya @ebisuyamiki.bsky.social · 17h

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...

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Shifaan Thowfeequ @shifaant.bsky.social · 15h

The 'sparks' of life! Our latest work on the role of #calcium dynamics in the early #embryo. 🎇🔬🐁

@idrm.ox.ac.uk @oxforddpag.bsky.social @srinivas-lab.bsky.social #lightsheetmicroscopy #GCAMP

PLOS Biology @plosbiology.org · 1d

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4

Epiblast Ca2+ waves propagate from the apical to basal domain. The images show selected time points from movies of E5.5 GCaMP6f embryos imaged using a ZEISS lattice light-sheet 7 microscope. Top row: An example of an epiblast wave involving a large proportion of the tissue captured by imaging a volume of the embryo at 20-s intervals. A total of 9/16 embryos showed at least one epiblast Ca2+ wave. Bottom row: Faster imaging at 5-s interval revealed that the Ca2+ wave in the epiblast can be preceded by a transient in a neighboring VE cell—this was observed in 5/19 events from 9 embryos (white arrowheads).

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Sheila Teves @sheilateves.bsky.social · 1d

How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription

Molecular determinants underlying functional divergence of TBP homologs

The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

www.biorxiv.org

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SEBD @sebioldev.bsky.social · 2d

We are very pleased to announce our joint meeting with the German @gfeev.bsky.social and the Dutch Developmental Biology Societies, which will take place in Potsdam from the 10-13th of March 2026. Registration is now open! www.uni-potsdam.de/en/gfe-meeti...

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Edda Schulz @eddaschulz.bsky.social · 2d

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

www.nature.com

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Reto Fiolka @retof.bsky.social · 2d

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

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Hao Yin @haoyin.bsky.social · 2d

#Senescence #Mechanobiology

Matrix #Viscoelasticity ⏬NIH3T3 Fibroblast Senescence (UV)

Polyacrylamide (3 kPa) + linear alginate polymer (for viscosity Loss modulus 0/100/200/300 Pa)
Does UV modify matrix mechanics?🧐

+⏫Integrin (Not FA-enriched)-YAP

#JMaterChemB 2025
pubs.rsc.org/en/content/a...

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Virtual Gastrulation Zoom Talks @vgzt2021.bsky.social · 2d

Dear VGZT enthusiasts,
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination

VGZT Season 7 - Nomination

Virtual Gastrulation Zoom Talks (VGZT) is an opportunity to share your science with an engaged, international audience of developmental biologists. Running from October 2025 to July 2026, this online ...

www.tinyurl.com

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dave dougan @douganlab.bsky.social · 3d

And now for something completely different in co-translational targeting: Molecular Cell www.cell.com/molecular-ce...

And now for something completely different in co-translational targeting

In two recent papers in Cell, Zhu et al. and Luo et al. use selective ribosome profiling to identify the substrates and timing of co-translational protein targeting to mitochondria. The results sugges...

www.cell.com

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Fillip Port @crisprflydesign.bsky.social · 4d

High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social

#CRISPR #Drosophila

www.biorxiv.org/content/10.1...

Figure from the preprint showing sensory neuron morphology with different levels of Cas9 expression.

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Kevin Terretaz @kwolbachia.bsky.social · 4d

I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager!
I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...

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Alliance of Genome Resources @alliancegenome.bsky.social · 5d

Nature has published an article on the crisis facing MODs
Model organism databases face budget cuts and closures www.nature.com/articles/d41...
@zfinmod.bsky.social @xenbase.bsky.social @yeastgenome.bsky.social @mousegenome.bsky.social @ratgenome.bsky.social @geneontology.bsky.social @nature.com

Model organism databases face budget cuts and closures

Beyond the crucial data they contain, these digital archives have provided an important space for academic communities to exchange ideas and resources.

www.nature.com

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Estefania Sanchez-Vasquez @niasv.bsky.social · 5d

🥰🥰🥰🥰

feña Palominos @fishfena.bsky.social · 5d

🚨 🚨 Science Alert: Join us by the end of the month at the @sacnas.bsky.social NDiSTEM 2025 Meeting! We’ll be hosting a workshop with Emma Rangel-Huerta from @stowersinstitute.bsky.social and @niasv.bsky.social from @ucscscience.bsky.social to talk about navigating a PhD in life sciences 🤩🫶

latinxdb.bsky.social @latinxdb.bsky.social · 6d

🚨LatinxDB organize: “Why didn’t I know this before? What to expect from a PhD or a postdoc in life sciences”

Thanks Estefania Vasquez, M. Fernanda Palominos and Emma Rangel for creating this space and discussion. @niasv.bsky.social @fishfena.bsky.social

Join us at 2025NDiSTEM @sacnas.bsky.social

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Latin American Developmental Biology @lasdb.bsky.social · 17d

We are pleased to announce the public call for proposals to host and organize the next LASDB Meeting, scheduled for 2027.
lasdb-development.org/pages/news.h...

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Development @dev-journal.bsky.social · 6d

Modifying mechanical constraint guides gastruloid patterning

This Research Highlight showcases the work from Judith Pineau @judithpineau.bsky.social, Jerome Wong-Ng @jeromewongng.bsky.social, Thomas Gregor @thomasgregor.bsky.social and colleagues:

journals.biologists.com/dev/article/...

Figure 2 - Gene expression patterning and transcriptional profiles in hydrogel-grown gastruloids. (A) Representative immunofluorescence images of gastruloids at 120 h. Gastruloids were grown in standard culture conditions (Ctrl, no hydrogel) or embedded in hydrogels with increasing concentrations (0.7 mM, 0.8 mM and 1.0 mM) at 96 h post-seeding. Nuclei (blue), BRA (purple) and SOX2 (yellow) are labeled. (B,C) Normalized expression profiles of SOX2 (B) and BRA (C) along the AP axis, demonstrating consistent expression patterns across conditions. (D) Principal component analysis of bulk RNA-seq experiments (three replicates), revealing clear separation between Ctrl and noCHI (red), a negative control for gastruloid formation, while hydrogel-embedded conditions cluster near Ctrl. (E) Number of significantly differentially expressed (DE) genes compared to Ctrl, showing substantial transcriptional changes in noCHI and minimal changes in hydrogel-embedded conditions (0.7 mM, 0.8 mM and 1.0 mM). Shown here are representative data and analysis for one experimental replicate. See Fig. S3 for two additional replicates.

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Ricard Solé @ricardsole.bsky.social · 7d

Looking forward to speak at this @embo.org Workshop event meetings.embo.org/event/25-mul... to explore the origins of multicellular complexity along with great colleagues @multicellgenome.bsky.social @wcratcliff.bsky.social @viktri08.bsky.social I will be discussing synthetic multicellularity.

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Ben Adler @benadler.bsky.social · 7d

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.

Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

www.nature.com

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Estefania Sanchez-Vasquez @niasv.bsky.social · 7d

Congrats!

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Bryce Manso, Ph.D. @brycemanso.bsky.social · 7d

A little late, but 🚨new paper alert!🚨
Interested in #aging, #blood, #StemCells, #HSCs, #platelets, or #MkPs? Read on!
onlinelibrary.wiley.com/doi/10.1111/...

A Rare Hematopoietic Stem Cell‐Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging

Manso et al. developed strategies for isolating and testing the functional mechanisms regulating age-specific megakaryocyte progenitors derived from hematopoietic stem cells.

onlinelibrary.wiley.com

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Estefania Sanchez-Vasquez @niasv.bsky.social · 7d

Amazing cover!!!

Genes & Development @genesdev.bsky.social · 7d

🚨 NEW ISSUE ALERT!!! 🚨

New Outlook, Review and Research Papers online now at Genes & Development.

Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/39/19-20.toc

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Vincent Pasque @pasquelab.bsky.social · 7d

Excited to share our latest News & Views published in Nature! @nature.com
rdcu.be/eI2NJ

Sherif Khodeer and I discuss how stem cell-based embryo models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.

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Johanna Joyce @johannajoyce.bsky.social · 7d

Such an important question to answer - why are more young people getting cancer?

#cancer #research 🧪🔬🧬

www.nytimes.com/2025/10/01/w...

Why Are More Young People Getting Cancer?

www.nytimes.com

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siddhartha jena @epijenatics.bsky.social · 27d

This work is a proof of concept towards fully programmable chromatin, something I think will become very common. By combining evolutionary insights, high-throughput assays and predictive/generative modeling, we should be able to uncover some true “superpowers” of chromatin (more on this soon!) 7/9

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