mixmue.bsky.social
Michaela Müller-McNicoll
@mixmue.bsky.social
500 followers 440 following 28 posts
RNAholic, Scientist, interested in architectural roles, packaging and binding codes #RNA, #splicing, #condensates
Posts Media Videos Starter Packs
Reposted by Michaela Müller-McNicoll
jorg-vogel-lab.bsky.social
Jörg Vogel @jorg-vogel-lab.bsky.social · 8h
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
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Reposted by Michaela Müller-McNicoll
kondadilab.bsky.social
Kondadi Lab @kondadilab.bsky.social · 1d
For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below:

gbm-online.de/de/tagungska...
2nd Meeting of the Study Group "Cellular Organelles" - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.
organized by Arun Kumar Kondadi and Andreas Reichert
gbm-online.de
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Reposted by Michaela Müller-McNicoll
martinahallegger.bsky.social
MaRtiNA Hallegger @martinahallegger.bsky.social · 4d
Stress granules have a limited impact on global translation regulation but serve to protect small ribosomal subunits and preinitiation complexes from degradation
rnadavid.bsky.social
David Kuster @rnadavid.bsky.social · 4d
Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...
Translation landscape of stress granules
Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.
www.science.org
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Reposted by Michaela Müller-McNicoll
hohmannulrich.bsky.social
Ulrich Hohmann @hohmannulrich.bsky.social · 16d
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...
www.biorxiv.org
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Reposted by Michaela Müller-McNicoll
katsufunai.bsky.social
Katsu Funai @katsufunai.bsky.social · 20d
Still true
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Reposted by Michaela Müller-McNicoll
hilgerslab.bsky.social
Hilgers Lab @hilgerslab.bsky.social · 19d
Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social !
genesdev.cshlp.org/content/earl...
Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.
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Reposted by Michaela Müller-McNicoll
imprs-cbp.bsky.social
IMPRS on Cellular Biophysics @imprs-cbp.bsky.social · 20d
We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.
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Reposted by Michaela Müller-McNicoll
gbmev.bsky.social
GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 20d
GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!
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Reposted by Michaela Müller-McNicoll
willgarland.bsky.social
William Garland @willgarland.bsky.social · 21d
How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens.
www.biorxiv.org/content/10.1...
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs, that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, including prote...
www.biorxiv.org
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Reposted by Michaela Müller-McNicoll
karsten-rippe.bsky.social
Karsten Rippe @karsten-rippe.bsky.social · Jul 11
Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...
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Reposted by Michaela Müller-McNicoll
sarawickstrom.bsky.social
Sara Wickstrom @sarawickstrom.bsky.social · 27d
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
jobs.mpi-muenster.mpg.de
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Reposted by Michaela Müller-McNicoll
jpkbravo.bsky.social
Jack Bravo @jpkbravo.bsky.social · 23d
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!

Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.

Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
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Reposted by Michaela Müller-McNicoll
imprs-cbp.bsky.social
IMPRS on Cellular Biophysics @imprs-cbp.bsky.social · 23d
We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students!
#imprs_cbp #biophysics #gradschool
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Reposted by Michaela Müller-McNicoll
imprs-cbp.bsky.social
IMPRS on Cellular Biophysics @imprs-cbp.bsky.social · 23d
We had a great start of the #IMPRS Symposium on Cellular Biophysics to welcome our new students. Thank you for your fascinating talks Michaela Müller-McNicoll, Bernhard Hampölz and Christian Münch 👏

#imprs_cbp #phd #biophysics
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Reposted by Michaela Müller-McNicoll
rosario-avolio.bsky.social
Rosario Avolio @rosario-avolio.bsky.social · 25d
Excited to share our recent work about the role of the molecular chaperone TRAP1 as RNA-binding protein! #RBPs #HGSOC
rnajournal.bsky.social
RNA Society Journal @rnajournal.bsky.social · 27d
TRAP1 moonlights as an RNA-binding protein, enhancing translation of the splicing factor LUC7L3 to drive proliferation in high-grade serous ovarian cancer cells. #TRAP1 #RBP #ovariancancer bit.ly/47t3apu
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mixmue.bsky.social
Michaela Müller-McNicoll @mixmue.bsky.social · 26d
Very cool story! congrats Markus and Niels!
landthalerm.bsky.social
Markus Landthaler @landthalerm.bsky.social · 26d
Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...
Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target transcripts within hours. Boehm et al. use conditional protein degradation and advanced transcriptomics to map t...
www.cell.com
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Reposted by Michaela Müller-McNicoll
paraspeckle.bsky.social
Miha Modic @paraspeckle.bsky.social · Sep 8
Beautiful mechanistic story, how QKI by bridging intronic motifs with U6 snRNA ensures inclusion of weak 5’ splice sites that are essential for building sarcomeres. Congrats @kurianlab.bsky.social and @evannostrandlab.bsky.social labs & all involved.
kurianlab.bsky.social
Kurianlab @kurianlab.bsky.social · Sep 8
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
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Reposted by Michaela Müller-McNicoll
zeinabrekad.bsky.social
Dr Zeinab Rekad 🔬🧬🧪 @zeinabrekad.bsky.social · Sep 7
#RNAsky
cp-trendsgenetics.bsky.social
Trends in Genetics @cp-trendsgenetics.bsky.social · Jul 8
"m6A in the coding sequence: linking deposition, translation and decay"
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues

"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."

Read it here:
authors.elsevier.com/sd/article/S...
Figure 2. Overview of N6-methyladenosine (m6A) decay pathways. m6A acts as a destabilizing mark on mRNA.
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Reposted by Michaela Müller-McNicoll
koolchemistry.bsky.social
koolchemistry.bsky.social @koolchemistry.bsky.social · Sep 5
New and simple chemical modifications to poly(A) tails extend protein expression -- a really easy one-pot method

Great work by Linglan Fang and Wenrui Zhong in our lab!

doi.org/10.1021/jacs.5c11900
Localized 2′-OH Acylation at Poly(A) Extends RNA Translation
The potential of coding RNAs as a general therapeutic modality is limited by their short intracellular lifetime. Here, we investigate the effects of localized post-transcriptional RNA modification on ...
doi.org
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Reposted by Michaela Müller-McNicoll
kurianlab.bsky.social
Kurianlab @kurianlab.bsky.social · Sep 6
www.sciencedirect.com/science/arti...
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
RNA-binding proteins (RBPs) are best known as effectors along the entire gene expression pathway and as constituents of RNA-protein machines such as t…
www.sciencedirect.com
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Reposted by Michaela Müller-McNicoll
heilemannlab.bsky.social
Heilemann Lab @heilemannlab.bsky.social · Sep 6
Congratulations, Dr. Li! 👏 🎉 @yunqingli.bsky.social @crc1507.bsky.social @dfg.de @goetheuni.bsky.social
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mixmue.bsky.social
Michaela Müller-McNicoll @mixmue.bsky.social · Sep 6
I am sooo excited. Starting tomorrow the next edition of the fabulous #emboiclip2 course begins. @koenig-lab.bsky.social, @zarnack-group.bsky.social, moi & Elias Bechara will present 3 improvements to the method, a semi-automated workflow for data analysis and an exciting line up of speakers. Ready?
mixmue.bsky.social
Michaela Müller-McNicoll @mixmue.bsky.social · Mar 13
Apply to our #EMBOiCLIP2 course in beautiful Genova this fall. Learn the latest version of the protocol, meet the experts in the field, analyze your own data and get to know fellow RNA aficionados.
meetings.embo.org/event/25-icl...
iCLIP2, mapping protein-RNA interactions: from A to Z
RNA is increasingly recognized as a key therapeutic target , driving the development of RNA-based therapeutics for a broad spectrum of diseases. RNA-binding proteins (RBPs) play a fundamental ro…
meetings.embo.org
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Reposted by Michaela Müller-McNicoll
zeinabrekad.bsky.social
Dr Zeinab Rekad 🔬🧬🧪 @zeinabrekad.bsky.social · Aug 29
#RNAsky
narjournal.bsky.social
Nucleic Acids Research @narjournal.bsky.social · Aug 29
⭐NAR Breakthrough!⭐

🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823

#NARBreakthrough #RNA #RNAHelicase
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Reposted by Michaela Müller-McNicoll
gbmev.bsky.social
GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · Aug 28
Wer Barbaras Rhabarberbarbarbaren mochte, freut sich hierüber auf jeden Fall auch. Und damit Gute Nacht!
malo82.bsky.social
Mathias mit 1 Tee @malo82.bsky.social · Aug 28
Bodo Wartke mit einem 58 Sekunden Zellbiologie Crashkurs - und Ribosomen kommen natürlich auch vor 🤩
Das endoplasmatische Retikulum
YouTube video by Bodo Wartke
m.youtube.com
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Reposted by Michaela Müller-McNicoll
svobodalab.bsky.social
Petr Svoboda @svobodalab.bsky.social · Aug 28
The original idea is from @lcochella.bsky.social, we just extended it a bit.
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